Generic Name: colistimethate (koe LIS ti METH ate)
Brand Names: Coly Mycin M
What is colistimethate?
Colistimethate is an antibiotic that fights bacteria in the body.
Colistimethate is used to treat infections caused by bacteria.
Colistimethate may also be used for purposes not listed in this medication guide.
What is the most important information I should know about colistimethate?
You should not use this medication if you are allergic to colistimethate.
Before using colistimethate, tell your doctor if you are allergic to any drugs, or if you have kidney disease. You may need a dose adjustment or special tests during treatment.
Colistimethate is given as an injection into a muscle or through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
Keep using colistimethate for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Colistimethate will not treat a viral infection such as the common cold or flu.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using colistimethate. You may need to stop using the medicine for a short time.
What should I discuss with my health care provider before taking colistimethate?
You should not use this medication if you are allergic to colistimethate.
Before using colistimethate, tell your doctor if you are allergic to any drugs, or if you have kidney disease. You may need dose adjustments or special tests during treatment.
Your doctor will tell you if any of your medication doses need to be changed.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether colistimethate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take colistimethate?
Colistimethate is given as an injection into a muscle or through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
The colistimethate injection is sometimes given every 12 hours. The medication can also be mixed with a liquid in an IV bag and given as a slow infusion over a 24-hour period.
Use each disposable needle and syringe only one time. Throw away used needles and syringes in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Use this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Keep using colistimethate for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Colistimethate will not treat a viral infection such as the common cold or flu.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using colistimethate. You may need to stop using the medicine for a short time. If you store colistimethate at home, keep the medication at cool room temperature away from moisture and heat. After colistimethate is mixed in an IV bag, it must be kept in a refrigerator and used within 7 days of mixing.
What happens if I miss a dose?
Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include confusion, dizziness, loss of balance or coordination, blurred vision, slurred speech, severe numbness or tingling, or trouble breathing.
What should I avoid while taking colistimethate?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Colistimethate side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
diarrhea that is watery or bloody;
fever;
urinating less than usual or not at all;
muscle weakness; or
trouble breathing.
Less serious side effects may include:
mild numbness or tingling in your hands or feet;
dizziness, spinning feeling;
itching, mild skin rash; or
upset stomach.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Colistimethate Dosing Information
Usual Adult Dose for Gram Negative Infection:
Parenteral: 2.5 to 5 mg/kg/day IM or IV in 2 to 4 divided doses
Inhalation: 50 to 75 mg in normal saline (3 to 4 mL total volume) via nebulizer 2 to 3 times a day has been suggested
Usual Pediatric Dose for Gram Negative Infection:
Parenteral: 2.5 to 5 mg/kg/day IM or IV in 2 to 4 divided doses
Inhalation:
Neonates: 4 mg/kg/dose every 12 hours has been used to treat ventilator-associated pneumonia
Infants, children, adolescents: 50 to 75 mg in normal saline (3 to 4 mL total volume) via nebulizer 2 to 3 times a day has been suggested
What other drugs will affect colistimethate?
The following antibiotics can interact with colistimethate. Tell your doctor if you are using any of these:
amikacin (Amikin);
gentamicin (Garamycin);
kanamycin (Kantrex);
neomycin (Mycifradin, Neo-Fradin, Neo-Tab);
netilmicin (Netromycin);
polymyxin;
streptomycin; or
tobramycin (Nebcin, Tobi).
This list is not complete and there may be other drugs that can interact with colistimethate. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
More colistimethate resources
- Colistimethate Side Effects (in more detail)
- Colistimethate Use in Pregnancy & Breastfeeding
- Colistimethate Drug Interactions
- Colistimethate Support Group
- 0 Reviews for Colistimethate - Add your own review/rating
- colistimethate Injection Advanced Consumer (Micromedex) - Includes Dosage Information
- Colistimethate MedFacts Consumer Leaflet (Wolters Kluwer)
- Colistimethate Prescribing Information (FDA)
- Colistimethate Sodium Monograph (AHFS DI)
Compare colistimethate with other medications
- Gram Negative Infection
Where can I get more information?
- Your pharmacist can provide more information about colistimethate.
See also: colistimethate side effects (in more detail)
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